US 11,918,955 B2
Biological fluid purification with biocompatible membranes
Charles C. Klassen, Boston, MA (US); Harald C. Ott, Wenham, MA (US); Maria Jaramillo, Swampscott, MA (US); Robert G. Hesse, Watertown, MA (US); and Daniel Cheng, Somerville, MA (US)
Assigned to IVIVA Medical, Inc., Woburn, MA (US)
Filed by IVIVA Medical, Inc., Woburn, MA (US)
Filed on Aug. 15, 2022, as Appl. No. 17/888,262.
Application 17/888,262 is a continuation of application No. 17/435,024, granted, now 11,413,580, issued on Aug. 16, 2022, previously published as PCT/US2020/020498, filed on Feb. 28, 2020.
Claims priority of provisional application 62/812,239, filed on Feb. 28, 2019.
Prior Publication US 2023/0046290 A1, Feb. 16, 2023
Int. Cl. B01D 61/18 (2006.01); A61L 27/40 (2006.01); A61M 1/16 (2006.01); A61M 1/28 (2006.01); A61M 1/34 (2006.01); B01D 61/14 (2006.01); B01D 61/28 (2006.01); B01D 63/06 (2006.01); B01D 63/08 (2006.01); B01D 67/00 (2006.01)
CPC B01D 61/18 (2013.01) [A61L 27/40 (2013.01); A61M 1/16 (2013.01); A61M 1/1678 (2013.01); A61M 1/1696 (2013.01); A61M 1/28 (2013.01); A61M 1/3417 (2014.02); A61M 1/3489 (2014.02); B01D 61/14 (2013.01); B01D 61/145 (2013.01); B01D 61/28 (2013.01); B01D 63/06 (2013.01); B01D 63/082 (2013.01); B01D 63/087 (2013.01); B01D 67/00111 (2022.08); A61M 2202/0021 (2013.01); A61M 2202/0413 (2013.01); A61M 2205/02 (2013.01); A61M 2205/75 (2013.01); B01D 2311/2626 (2013.01); B01D 2313/08 (2013.01); B01D 2313/54 (2013.01); B01D 2313/68 (2022.08); B01D 2319/06 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An apparatus for restoring or supplementing pancreatic function comprising:
a functional unit comprising:
a membrane comprising a first surface and a second surface;
a first channel system comprising a first luminal space, adhered to and in fluid communication with the first surface of the membrane, and comprising a first end configured to connect in fluid communication to a fluid supply and a second end configured to connect in fluid communication to a first fluid outlet;
a second channel system comprising a second luminal space, adhered to and in fluid communication with the second surface of the membrane, and comprising a third end configured to connect in fluid communication to a second fluid outlet;
wherein the first channel system and the second channel system are in fluid communication with each other across the membrane;
wherein each of the first and second channel systems comprise first and second channel system walls; and
wherein the second channel system has been populated with pancreatic islet cells, including beta cells, to generate functional, live pancreatic tissue adhered to the second channel system walls thereof.
 
15. A method of treating a patient having an insufficient pancreas function comprising fluidly connecting the apparatus of claim 1 to a circulation system of the patient and passing patient blood through the first channel system of the apparatus and back into the circulation system of the patient.