	US 11,918,718 B2
	Molecularly imprinted polymers for removal of trimethylamine N-oxide
Buddy D. Ratner, Seattle, WA (US); and Runbang Tang, Seattle, WA (US)
Assigned to University of Washington, Seattle, WA (US)
Filed by University of Washington, Seattle, WA (US)
Filed on Nov. 18, 2022, as Appl. No. 18/056,994.
Application 18/056,994 is a division of application No. 16/837,828, filed on Apr. 1, 2020, granted, now 11,524,275.
Claims priority of provisional application 62/828,340, filed on Apr. 2, 2019.
Prior Publication US 2023/0173459 A1, Jun. 8, 2023
Int. Cl. B01J 20/26 (2006.01); A61M 1/16 (2006.01); B01D 15/38 (2006.01); B01J 20/28 (2006.01)

CPC A61M 1/1696 (2013.01) [B01D 15/3852 (2013.01); B01J 20/267 (2013.01); B01J 20/268 (2013.01); B01J 20/28004 (2013.01)]

5 Claims

1. A method of making a crosslinked polymer, comprising:

polymerizing a monomer comprising a (C_0-6alkyl)acrylic acid, di(C_1-6alkyl)acrylic acid, or a combination thereof; and a crosslinker comprising a (C_1-6alkylene glycol)-di(C_1-6alkyl)acrylate, trimethylolpropane trimethacrylate, N,N′-methylenebisacrylamide, or any combination thereof; at a monomer:crosslinker ratio of from 1:9 to 14:1, in the presence of trimethylamine N-oxide and a solvent, to provide the crosslinked polymer,

wherein the crosslinked polymer comprises specific binding sites for trimethylamine N-oxide and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g.