US 11,918,582 B2
Pyrazole pyrimidine compounds and uses thereof
Cyril Bucher, San Mateo, CA (US); Adrian Dukes, South San Francisco, CA (US); Blanca Gomez, South San Francisco, CA (US); Hannah Haley, South San Francisco, CA (US); Dennis Hu, San Mateo, CA (US); Jeffrey J. Jackson, San Bruno, CA (US); Michelle Yoo Min Ko, San Francisco, CA (US); Paul Leger, South San Francisco, CA (US); Anqi Ma, South San Francisco, CA (US); Andrew A. Ng, South San Francisco, CA (US); Daniel Poon, South San Francisco, CA (US); Omar Robles, Redwood City, CA (US); Anton Shakhmin, South San Francisco, CA (US); Grant Shibuya, South San Francisco, CA (US); Parcharee Tivitmahaisoon, South San Francisco, CA (US); Vi-Anh Vu, South San Francisco, CA (US); David J. Wustrow, South San Francisco, CA (US); and Mikhail Zibinsky, Redwood City, CA (US)
Assigned to RAPT Therapeutics, Inc., South San Francisco, CA (US)
Filed by RAPT Therapeutics, Inc., South San Francisco, CA (US)
Filed on Mar. 14, 2022, as Appl. No. 17/694,642.
Claims priority of provisional application 63/161,426, filed on Mar. 15, 2021.
Prior Publication US 2022/0305018 A1, Sep. 29, 2022
Int. Cl. A61K 31/519 (2006.01); A61K 45/06 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01)
CPC A61K 31/519 (2013.01) [A61K 45/06 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01)] 57 Claims
 
1. A compound of formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein:
L is a bond or a substituted or unsubstituted methylene;
X is not bonded directly to the N atom of N—R1 and is either absent or if present is a substituted or unsubstituted alkyl;
Y is CH or N;
Z is CR2 or N;
each of n and m is 0, 1 or 2, and (n+m) equals 1, 2 or 3;
p is 0, 1, 2 or 3;
R1 is H, or a substituted or unsubstituted alkyl;
R2 is H, a halogen, a substituted or unsubstituted alkyl or a substituted or unsubstituted heteroalkyl;
R3 is H, or a substituted or unsubstituted heteroalkyl;
R4 is H, a substituted or unsubstituted alkyl or a halogen; and
R5 is a substituted or unsubstituted alkyl, a substituted or unsubstituted heteroalkyl, a substituted or unsubstituted cycloalkyl or a substituted or unsubstituted heterocycloalkyl.