US 11,918,570 B2
Method of treatment for prevention of glucocorticoid toxicity and/or enhancement of muscle regeneration via neutrophil elastase inhibition
Addolorata Pisconti, Port Jefferson, NY (US); Fiona Kate Jones, East Setauket, NY (US); and Kirsty Anne Johnson, Wirral (GB)
Assigned to The Research Foundation for The State University of New York, Albany, NY (US); and The University of Liverpool, Liverpool (GB)
Filed by The Research Foundation for The State University of New York, Albany, NY (US); and The University of Liverpool, Liverpool (GB)
Filed on Apr. 13, 2021, as Appl. No. 17/228,931.
Claims priority of provisional application 63/009,038, filed on Apr. 13, 2020.
Prior Publication US 2021/0315873 A1, Oct. 14, 2021
Int. Cl. A61K 31/444 (2006.01); A61K 31/573 (2006.01); A61P 21/00 (2006.01)
CPC A61K 31/444 (2013.01) [A61K 31/573 (2013.01); A61P 21/00 (2018.01)] 13 Claims
 
1. A method for promoting muscle regeneration in a subject with a myopathy comprising administering to the subject in need thereof a synergistically effective amount of an elastase inhibitor in combination with a glucocorticoid, wherein the elastase inhibitor is alvelestat and the glucocorticoid is prednisolone.