US 12,243,648 B2
Evaluation of donor lungs during ex-vivo lung perfusion
Kamal S. Ayyat, Cleveland, OH (US); Toshihiro Okamoto, Cleveland, OH (US); and Kenneth R. McCurry, Cleveland, OH (US)
Assigned to THE CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US)
Filed by THE CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US)
Filed on Apr. 22, 2022, as Appl. No. 17/726,746.
Claims priority of provisional application 63/178,190, filed on Apr. 22, 2021.
Prior Publication US 2022/0344056 A1, Oct. 27, 2022
Int. Cl. G06T 7/00 (2017.01); G16H 10/60 (2018.01); G16H 30/40 (2018.01); G16H 50/30 (2018.01)
CPC G16H 50/30 (2018.01) [G06T 7/0012 (2013.01); G16H 10/60 (2018.01); G16H 30/40 (2018.01); G06T 2200/24 (2013.01); G06T 2207/10116 (2013.01); G06T 2207/10132 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/30061 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A system for evaluating a donor lung undergoing ex-vivo perfusion, the system comprising:
a processor; and
a non-transitory computer readable medium storing executable instructions, the executable instructions comprising:
a feature extractor configured to generate a plurality of parameters representing the donor lung undergoing ex-vivo perfusion, wherein a first set of at least one of the plurality of parameters are ordinal categorical parameters that can assume one of a plurality of categorical values and a second set of at least one of the plurality of parameters are each continuous parameters;
a score calculator configured to apply, for each of the second set of at least one of the plurality of parameters, a set of rules associated with the parameter to assign an ordinal categorical value from a plurality of ordinal categorical values to the parameter, assign a numerical value to each of the first set of at least one of the plurality of parameters and each of the second set of at least one of the plurality of parameters according to the categorical value associated with the parameter, and determine a composite score representing a suitability of the donor lung undergoing ex-vivo perfusion for transplant from the plurality of parameters; and
a user interface configured to provide an output representing the composite score to a user at an associated output device.