| CPC G16H 20/40 (2018.01) [A61B 5/0215 (2013.01); A61B 6/032 (2013.01); A61B 6/4417 (2013.01); A61B 6/504 (2013.01); A61B 6/5217 (2013.01); A61B 8/04 (2013.01); A61B 8/12 (2013.01); G16H 50/30 (2018.01); A61B 2034/102 (2016.02); A61B 2034/104 (2016.02); A61B 2034/107 (2016.02); A61B 2034/108 (2016.02)] | 17 Claims |

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1. A system, comprising:
a pressure-sensing guidewire configured to be positioned within a vessel of a patient, wherein the pressure-sensing guidewire comprises a proximal portion, a distal portion, and a pressure sensor coupled to the distal portion; and
a processor configured for communication with the pressure-sensing guidewire, wherein the processor is configured to:
obtain a plurality of pressure measurements from the pressure-sensing guidewire at a plurality of locations along the vessel and a pressure-sensing instrument;
determine, based on the plurality of pressure measurements, a plurality of pressure ratios corresponding to the plurality of locations;
obtain an external image of the vessel;
co-register the plurality of pressure ratios with the plurality of locations in the external image;
determine, using a disease quantification score (DSQ) calculator, a total DSQ associated with the vessel, wherein the total DSQ [score] comprises a first contribution from a first segment of the vessel and a second contribution from a second segment of the vessel;
generate a pressure-based view of the external image based on the plurality of pressure ratios, wherein the pressure-based view comprises a plurality of pressure ratio markers distributed along the vessel in the external image at the corresponding plurality of locations;
generate a DSQ-based view of the external image based on the total DSQ, wherein the DSQ-based view comprises:
the external image; and
a first numerical value of the first contribution overlaid on the external image at a first location of the vessel specific to the first segment; and
output, to a display in communication with the processor, a user interface comprising:
an external image area comprising one of the pressure-based view or the DSQ-based view; and
a numerical value of the total DSQ.
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