US 12,241,898 B2
Reagents for directed biomarker signal amplification
Brent S. Gaylord, San Diego, CA (US); Glenn P. Bartholomew, Escondido, CA (US); Russell A. Baldocchi, Encinitas, CA (US); Janice W. Hong, San Diego, CA (US); William H. Huisman, San Diego, CA (US); Yongchao Liang, Irvine, CA (US); Trung Nguyen, San Diego, CA (US); Lan T. Tran, Oceanside, CA (US); Jean M. Wheeler, San Diego, CA (US); Adrian Charles Vernon Palmer, Brighton (GB); and Frank Peter Uckert, San Diego, CA (US)
Assigned to SIRIGEN II LIMITED, Oxford (GB)
Filed by SIRIGEN II LIMITED, Berkshire (GB)
Filed on Jan. 6, 2023, as Appl. No. 18/094,132.
Application 18/094,132 is a continuation of application No. 17/726,409, filed on Apr. 21, 2022, granted, now 11,874,278.
Application 17/726,409 is a continuation of application No. 17/712,462, filed on Apr. 4, 2022.
Application 17/712,462 is a continuation of application No. 16/358,492, filed on Mar. 19, 2019, granted, now 11,333,666, issued on May 17, 2022.
Application 16/358,492 is a continuation of application No. 15/717,502, filed on Sep. 27, 2017, granted, now 10,302,648, issued on May 28, 2019.
Application 15/717,502 is a continuation of application No. 15/239,713, filed on Aug. 17, 2016, granted, now 10,094,838, issued on Oct. 9, 2018.
Application 15/239,713 is a continuation of application No. 14/821,386, filed on Aug. 7, 2015, granted, now 9,547,008, issued on Jan. 17, 2017.
Application 14/821,386 is a continuation of application No. 14/018,985, filed on Sep. 5, 2013, granted, now 9,139,869, issued on Sep. 22, 2015.
Application 14/018,985 is a continuation of application No. 13/009,764, filed on Jan. 19, 2011, granted, now 8,575,303, issued on Nov. 5, 2013.
Claims priority of provisional application 61/358,406, filed on Jun. 24, 2010.
Claims priority of provisional application 61/296,379, filed on Jan. 19, 2010.
Prior Publication US 2023/0251264 A1, Aug. 10, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/58 (2006.01); C07K 16/28 (2006.01); C08G 61/02 (2006.01); C09B 57/00 (2006.01); C09B 67/00 (2006.01); C09B 69/00 (2006.01); C12Q 1/6818 (2018.01); C12Q 1/682 (2018.01); H10K 85/10 (2023.01)
CPC G01N 33/58 (2013.01) [C07K 16/2812 (2013.01); C07K 16/2815 (2013.01); C08G 61/02 (2013.01); C09B 57/00 (2013.01); C09B 68/41 (2013.01); C09B 69/00 (2013.01); C12Q 1/6818 (2013.01); C12Q 1/682 (2013.01); G01N 33/582 (2013.01); H10K 85/151 (2023.02); C08G 2261/1424 (2013.01); C08G 2261/3142 (2013.01); C08G 2261/411 (2013.01); H10K 85/115 (2023.02)] 30 Claims
OG exemplary drawing
 
1. A complex comprising:
(a) a conjugated polymer comprising π-conjugated repeat units, wherein the π-conjugated repeat units comprise:
a non-ionic Ar polycyclic repeat unit that is evenly or randomly distributed along the polymer main chain;
an MU polymer modifying unit that is evenly or randomly distributed along the polymer main chain; and
a linker L1 that is an aryl or a heteroaryl group evenly or randomly distributed along the polymer main chain; and
G1 and G2 terminating groups, wherein at least one of G1 and G2 is aryl or substituted aryl and G1 and G2 are different from Ar, MU and L1; and
(b) a sensor biomolecule.