US 12,241,896 B2
Proteomic assay using quantum sensors
Jason Paul Cleveland, Boulder, CO (US); Karoly Holczer, Los Angeles, CA (US); and Barry Patrick John Vant-Hull, Boulder, CO (US)
Assigned to SomaLogic Operating Co., Inc., Boulder, CO (US)
Filed by SomaLogic Operating Co., Inc., Boulder, CO (US)
Filed on Jul. 11, 2023, as Appl. No. 18/350,379.
Application 18/350,379 is a continuation of application No. 17/672,089, filed on Feb. 15, 2022, granted, now 11,698,373.
Application 17/672,089 is a continuation of application No. 16/686,911, filed on Nov. 18, 2019, granted, now 11,249,080, issued on Feb. 15, 2022.
Application 16/686,911 is a continuation of application No. 15/917,524, filed on Mar. 9, 2018, granted, now 10,481,155, issued on Nov. 19, 2019.
Prior Publication US 2023/0349896 A1, Nov. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/543 (2006.01); G01N 21/64 (2006.01); G01N 21/77 (2006.01); G01N 21/78 (2006.01); G01N 24/08 (2006.01); G01N 33/487 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01); G01R 33/32 (2006.01)
CPC G01N 33/54386 (2013.01) [G01N 21/64 (2013.01); G01N 21/78 (2013.01); G01N 24/088 (2013.01); G01N 33/487 (2013.01); G01N 33/5308 (2013.01); G01N 33/54306 (2013.01); G01N 33/6803 (2013.01); G01R 33/323 (2013.01); G01N 21/6489 (2013.01); G01N 2021/6495 (2013.01); G01N 2021/7783 (2013.01); G01N 2570/00 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A device for detecting label-free target analytes, comprising:
a surface configured to contact a fluid;
at least two capture reagents attached to the surface, the at least two capture reagents being configured to bind to different label-free target analytes respectively;
a plurality of color centers located proximate the surface; and
at least one detector configured to detect a change in a property of at least one of the color centers in response to binding one of the different label-free target analytes to a corresponding one of the capture reagents;
wherein the capture reagents are aptamers each having a negatively charged backbone.