US 12,241,851 B2
System and method for processing analyte signals in GMR-based detection of biomarkers
Todd Michael Klein, Wayzata, MN (US); Michael Monroe Reinhart Sandstedt, Minneapolis, MN (US); and Keping Song, Lauderdale, MN (US)
Assigned to Zepto Life Technology, Inc., St. Paul, MN (US)
Appl. No. 15/734,395
Filed by Zepto Life Technology, Inc., St. Paul, MN (US)
PCT Filed Jul. 26, 2019, PCT No. PCT/US2019/043791
§ 371(c)(1), (2) Date Dec. 2, 2020,
PCT Pub. No. WO2020/023934, PCT Pub. Date Jan. 30, 2020.
Claims priority of provisional application 62/711,396, filed on Jul. 27, 2018.
Prior Publication US 2021/0172927 A1, Jun. 10, 2021
Int. Cl. G01N 27/12 (2006.01); B01L 3/00 (2006.01); G01N 27/74 (2006.01); G01N 33/18 (2006.01); G01N 33/487 (2006.01); G01N 33/49 (2006.01); G01N 33/493 (2006.01); G01N 33/543 (2006.01); G01R 33/09 (2006.01); G01R 33/12 (2006.01)
CPC G01N 27/12 (2013.01) [B01L 3/502715 (2013.01); B01L 3/50273 (2013.01); B01L 3/567 (2013.01); G01N 27/74 (2013.01); G01N 27/745 (2013.01); G01N 33/1813 (2013.01); G01N 33/48707 (2013.01); G01N 33/49 (2013.01); G01N 33/493 (2013.01); G01N 33/54306 (2013.01); G01R 33/093 (2013.01); G01R 33/1269 (2013.01); G01R 33/1276 (2013.01); B01L 2200/026 (2013.01); B01L 2200/027 (2013.01); B01L 2200/04 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/14 (2013.01); B01L 2200/16 (2013.01); B01L 2300/025 (2013.01); B01L 2300/0663 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0883 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/123 (2013.01); B01L 2300/14 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/06 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A signal processing system used for Giant Magneto-Resistive (GMR)-based detection of a target analyte in a sample under test, comprising:
a measurement circuit configuration unit configured to build a GMR sensor measurement circuit by routing in at least one GMR sensor, and to build a reference resistor measurement circuit by routing in at least one reference resistor, the GMR sensor measurement circuit comprising at least one GMR sensor voltage divider, and the reference resistor measurement circuit comprising at least one reference resistor voltage divider;
a magnetic field excitation unit configured to apply an Alternating Current (AC) magnetic field of frequency ω2 to the at least one GMR sensor;
a carrier signal applying unit configured to apply a carrier signal of frequency ω1 to the GMR sensor measurement circuit, and apply carrier signals of frequency ω1, and ω1+ω2, and ω1−ω2 to the reference resistor measurement circuit;
a measurement signal pick-up unit coupled to the measurement circuits, configured to collect reference resistor measurement signals from the reference resistor measurement circuit and GMR sensor measurement signals from the GMR sensor measurement circuit; and
a phase sensitive solution unit coupled to the measurement signal pick-up unit, configured to analytically solve for resistance change of the at least one GMR sensor based on both the reference resistor measurement signals from the reference resistor measurement circuit and the GMR sensor measurement signals from the GMR sensor measurement circuit.