US 12,241,834 B2
Articles and methods for performing assays
Tae Kang, Campbell, CA (US); Stewart Holloway, San Jose, CA (US); and Michael Youngquist, Palo Alto, CA (US)
Assigned to Sartorius BioAnalytical Instruments, Inc., Bohemia, NY (US)
Appl. No. 18/579,324
Filed by Sartorius BioAnalytical Instruments, Inc., Bohemia, NY (US)
PCT Filed Jul. 6, 2022, PCT No. PCT/US2022/036194
§ 371(c)(1), (2) Date Jan. 12, 2024,
PCT Pub. No. WO2023/287618, PCT Pub. Date Jan. 19, 2023.
Claims priority of provisional application 63/221,690, filed on Jul. 14, 2021.
Prior Publication US 2024/0280487 A1, Aug. 22, 2024
Int. Cl. G01N 21/64 (2006.01)
CPC G01N 21/6428 (2013.01) [G01N 21/645 (2013.01); G01N 2021/6439 (2013.01); G01N 2021/6482 (2013.01); G01N 2021/6491 (2013.01)] 23 Claims
OG exemplary drawing
 
1. An instrument for performing an assay, comprising:
a probe;
a support structure positioned proximal to the probe, wherein a container for one or more fluids is positioned on the support structure; and
an optical detector configured to detect an optical signal, wherein:
a reagent is immobilized on the probe,
the probe is capable of being translated by the instrument between a plurality of locations at which a plurality of fluids are positioned, and
the optical signal comprises:
light that has been emitted and/or transmitted from a species immobilized on the probe,
light that has been emitted, transmitted, reflected, and/or scattered from a species generated from a species immobilized on the probe,
the absence of light due to absorption of light by a species immobilized on the probe, and/or
the absence of light due to absorption of light by a species generated from a species immobilized on the probe.