US 12,241,082 B2
Cell culturing materials
Lucas Johannes Anna Maria Beckers, Veldhoven (NL); and Jan Cornelis Kriege, Mierlo (NL)
Assigned to Koninklijke Philips N.V., Eindhoven (NL)
Appl. No. 16/630,872
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Jul. 6, 2018, PCT No. PCT/EP2018/068318
§ 371(c)(1), (2) Date Jan. 14, 2020,
PCT Pub. No. WO2019/015988, PCT Pub. Date Jan. 24, 2019.
Claims priority of application No. 17181788 (EP), filed on Jul. 18, 2017.
Prior Publication US 2020/0148999 A1, May 14, 2020
Int. Cl. C12N 5/00 (2006.01); C07K 14/47 (2006.01); C12M 1/00 (2006.01); C12M 1/12 (2006.01); C12M 1/42 (2006.01); C12M 3/00 (2006.01); C12N 5/071 (2010.01); C12Q 3/00 (2006.01); G16B 5/20 (2019.01)
CPC C12N 5/0068 (2013.01) [C07K 14/4702 (2013.01); C12M 21/00 (2013.01); C12M 21/08 (2013.01); C12M 23/26 (2013.01); C12M 23/34 (2013.01); C12M 25/14 (2013.01); C12M 35/08 (2013.01); C12N 5/068 (2013.01); C12Q 3/00 (2013.01); G16B 5/20 (2019.02); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2533/30 (2013.01); C12N 2533/40 (2013.01); C12N 2533/52 (2013.01); C12N 2537/10 (2013.01)] 20 Claims
 
1. A material for binding to a cell culturing protein, the material comprising:
a bulk-modified elastomer,
wherein the bulk-modified elastomer comprises a plurality of fatty acid moieties covalently bound to the elastomer bulk,
wherein the plurality of fatty acid moieties includes a first group and a second group,
wherein the first group of the fatty acid moieties is disposed internally within the bulk of the bulk-modified elastomer, and
wherein carboxylic acid groups of the second group of the fatty acid moieties are available at a surface of the bulk-modified elastomer to provide the binding to the cell culturing protein.