US 12,241,080 B2
Bacteriophage-based artificial viruses for human genome remodeling
Venigalla B. Rao, Washington, DC (US); and Jingen Zhu, Washington, DC (US)
Assigned to The Catholic University of America, Washington, DC (US)
Filed by The Catholic University of America, Washington, DC (US)
Filed on Dec. 9, 2021, as Appl. No. 17/546,183.
Application 17/546,183 is a division of application No. 17/359,711, filed on Jun. 28, 2021, granted, now 11,401,530.
Application 17/359,711 is a continuation in part of application No. 16/990,289, filed on Aug. 11, 2020, granted, now 11,155,835, issued on Oct. 26, 2021.
Claims priority of provisional application 62/888,576, filed on Aug. 19, 2019.
Claims priority of provisional application 63/058,012, filed on Jul. 29, 2020.
Prior Publication US 2022/0090139 A1, Mar. 24, 2022
Int. Cl. C12N 15/86 (2006.01); C12N 7/00 (2006.01)
CPC C12N 15/86 (2013.01) [C12N 7/00 (2013.01); C12N 2795/00043 (2013.01); C12N 2795/00051 (2013.01)] 6 Claims
 
1. A human genome remodeling artificial virus (AV) comprising:
a T4 capsid;
a Cas9 protein;
at least one RNA;
at least one DNA; and
a lipid coating,
wherein the DNA is packaged inside the T4 capsid;
wherein the RNA is selected from the group consisting of a mRNA, a siRNA, and a gRNA,
wherein the lipid coating comprises at least one cationic lipid.