	US 12,240,910 B2
	Anti-C-C motif chemokine receptor 8 (CCR8) antibodies and methods of use
Gautham Gampa, South San Francisco, CA (US); Iraj Hosseini, South San Francisco, CA (US); Mahrukh Huseni, South San Francisco, CA (US); James Thomas Koerber, San Mateo, CA (US); Jian Mehr-Dean Payandeh, Belmont, CA (US); Sascha Rutz, South San Francisco, CA (US); Yonglian Sun, South San Francisco, CA (US); Cecilia P. C. Chiu, Redwood City, CA (US); and Teresita Arenzana Delfino, Daly City, CA (US)
Assigned to Genentech, Inc., South San Francisco, CA (US)
Filed by GENENTECH, INC., South San Francisco, CA (US)
Filed on Jul. 13, 2022, as Appl. No. 17/864,074.
Claims priority of provisional application 63/253,676, filed on Oct. 8, 2021.
Claims priority of provisional application 63/221,734, filed on Jul. 14, 2021.
Prior Publication US 2023/0049152 A1, Feb. 16, 2023
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01)

CPC C07K 16/2866 (2013.01) [A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 16/2827 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/40 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)]

47 Claims

1. A monoclonal antibody that binds to C—C motif chemokine receptor 8 (CCR8), wherein the antibody comprises a heavy chain variable domain (VH) comprising (a) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 29 or SEQ ID NO: 30, (b) a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 31, and (c) a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 32, and a light chain variable domain (VL) comprising (d) a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 26, (e) a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 27, and (f) a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 28.