US 12,240,859 B2
Turbinmicin compounds, compositions and uses thereof
Timothy Bugni, Madison, WI (US); Fan Zhang, Madison, WI (US); Douglas R. Braun, Mount Horeb, WI (US); David Andes, Verona, WI (US); and Miao Zhao, Madison, WI (US)
Assigned to Wisconsin Alumni Research Foundation, Madison, WI (US)
Appl. No. 17/420,117
Filed by Wisconsin Alumni Research Foundation, Madison, WI (US)
PCT Filed Dec. 27, 2019, PCT No. PCT/US2019/068786
§ 371(c)(1), (2) Date Jun. 30, 2021,
PCT Pub. No. WO2020/146155, PCT Pub. Date Jul. 16, 2020.
Claims priority of provisional application 62/790,862, filed on Jan. 10, 2019.
Prior Publication US 2022/0119402 A1, Apr. 21, 2022
Int. Cl. C07D 491/16 (2006.01); A61K 45/06 (2006.01)
CPC C07D 491/16 (2013.01) [A61K 45/06 (2013.01)] 21 Claims
 
1. A compound having the structure of Formula I, Formula II, or a stereoisomer thereof, in isolated form

OG Complex Work Unit Chemistry
wherein:
R1 is

OG Complex Work Unit Chemistry
in Formula I;
R1 is C(O)—R2 in Formula II,
wherein R2 is a substituted or unsubstituted alkyl or alkenyl group;
provided that R1 is not 1-oxo-oct-2,4,6-trienyl.