US 12,240,857 B2
Adamantane derivatives for the treatment of filovirus infection
Michael Bruno Plewe, San Diego, CA (US); Eric Brown, San Diego, CA (US); Vidyasagar Gantla, San Diego, CA (US); Gregory Henkel, San Diego, CA (US); Kenneth McCormack, San Diego, CA (US); and Nadezda Sokolova, San Diego, CA (US)
Assigned to Arisan Therapeutics Inc., Carlsbad, CA (US)
Filed by Arisan Therapeutics Inc., Carlsbad, CA (US)
Filed on Jul. 12, 2018, as Appl. No. 16/033,636.
Application 16/033,636 is a continuation in part of application No. PCT/US2017/013560, filed on Jan. 13, 2017.
Prior Publication US 2020/0017514 A1, Jan. 16, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 487/10 (2006.01); A61P 31/14 (2006.01); C07C 233/62 (2006.01); C07D 205/04 (2006.01); C07D 207/12 (2006.01); C07D 211/98 (2006.01); C07D 295/195 (2006.01); C07D 487/08 (2006.01)
CPC C07D 487/10 (2013.01) [A61P 31/14 (2018.01); C07C 233/62 (2013.01); C07D 205/04 (2013.01); C07D 207/12 (2013.01); C07D 211/98 (2013.01); C07D 295/195 (2013.01); C07D 487/08 (2013.01); C07C 2603/74 (2017.05)] 20 Claims
 
17. A compound represented by Structural Formula I

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, and a pharmaceutically acceptable carrier, diluent, or vehicle thereof, wherein:
X is C-D, and Y is a bond;
D is selected from the group consisting of

OG Complex Work Unit Chemistry
R1 is selected from (C to C10) aryl, wherein (C to C10) aryl is optionally substituted with at least one R13 group;
R2 is selected from (C1 to C10) alkyl, (C1 to C10) alkoxy, and —C(O)OR12, wherein (C1 to C10) alkyl is optionally substituted with at least one R13 group;
R3 is selected from hydrogen and (C1 to C10) alkyl;
each R8 is independently selected from hydrogen and (C1 to C10) alkyl;
each of the R9a and R9b is independently selected from hydrogen, halogen, (C1 to C10) alkyl, and —C(O)OR12;
each of the R12 is independently selected from (C1 to C10) alkyl;
each R13 is independently selected from hydrogen, OH, nitro, (C1 to C10) alkyl, and (C1 to C10) alkoxy;
j is independently selected from 0 or 1.