US 12,240,847 B2
Process for making palbociclib
Petr Mitas, Blansko (CZ); and Oldrich Smekal, Blansko (CZ)
Assigned to Synthon B.V., Nijmegen (NL)
Filed by SYNTHON B.V., Nijmegen (NL)
Filed on Sep. 26, 2023, as Appl. No. 18/474,840.
Application 18/474,840 is a continuation of application No. 17/057,425, granted, now 11,858,928, previously published as PCT/EP2019/063085, filed on May 21, 2019.
Claims priority of application No. 18174119 (EP), filed on May 24, 2018.
Prior Publication US 2024/0034732 A1, Feb. 1, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 471/04 (2006.01)
CPC C07D 471/04 (2013.01) 11 Claims
 
1. A process for preparation of a compound of formula (1) or a salt thereof,

OG Complex Work Unit Chemistry
the process comprising:
(a) reacting in a solvent mixture comprising methanol and butanol, a compound of formula (3) and a compound of formula (4) to provide a compound of formula (2),

OG Complex Work Unit Chemistry
and
(b) transforming the compound of formula (2) into the compound of formula (1) or a salt thereof.