US 12,240,826 B2
Method for producing crystal of uracil compound
Yuki Sato, Hyogo (JP)
Assigned to SUMITOMO CHEMICAL COMPANY, LIMITED, Tokyo (JP)
Filed by Sumitomo Chemical Company, Limited, Tokyo (JP)
Filed on Jun. 28, 2021, as Appl. No. 17/359,870.
Application 16/883,237 is a division of application No. 16/308,254, granted, now 10,752,608, issued on Aug. 25, 2020, previously published as PCT/JP2017/025498, filed on Jul. 13, 2017.
Application 17/359,870 is a continuation of application No. 16/883,237, filed on May 26, 2020, granted, now 11,091,461.
Claims priority of application No. 2016-140053 (JP), filed on Jul. 15, 2016; application No. 2016-248827 (JP), filed on Dec. 22, 2016; and application No. 2017-055556 (JP), filed on Mar. 22, 2017.
Prior Publication US 2021/0323943 A1, Oct. 21, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/12 (2006.01); A01N 43/54 (2006.01)
CPC C07D 401/12 (2013.01) [A01N 43/54 (2013.01); C07B 2200/13 (2013.01)] 1 Claim
 
1. A method for producing a crystalline uracil compound represented by formula (1)

OG Complex Work Unit Chemistry
the method comprising
(Step 1) reacting a compound represented by formula (A1)

OG Complex Work Unit Chemistry
with an alkyl trifluoroacetoacetate;
(Step 2) reacting a crude product comprising a compound represented by formula (A3) obtained in Step 1

OG Complex Work Unit Chemistry
with a cyanate in the presence of a protonic acid; and
(Step 3) reacting a crude product comprising a compound represented by formula (A4) obtained in Step 2

OG Complex Work Unit Chemistry
with a methylating agent in the presence of a base.