US 12,240,821 B2
Inhibitors of guanosine monophosphate synthetase as therapeutic agents
Chao Zhang, Los Angeles, CA (US); Feng Ni, Los Angeles, CA (US); Arunika Ekanayake, Los Angeles, CA (US); and Biancha Espinosa, Los Angeles, CA (US)
Assigned to University of Southern California, Los Angeles, CA (US)
Appl. No. 17/274,736
Filed by University of Southern California, Los Angeles, CA (US)
PCT Filed Jul. 12, 2019, PCT No. PCT/US2019/041635
§ 371(c)(1), (2) Date Mar. 9, 2021,
PCT Pub. No. WO2020/055504, PCT Pub. Date Mar. 19, 2020.
Claims priority of provisional application 62/730,871, filed on Sep. 13, 2018.
Prior Publication US 2022/0048866 A1, Feb. 17, 2022
Int. Cl. C07D 239/94 (2006.01); A61K 31/167 (2006.01); A61K 31/517 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07C 235/56 (2006.01); C07C 237/42 (2006.01)
CPC C07D 239/94 (2013.01) [A61K 31/167 (2013.01); A61K 31/517 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07C 235/56 (2013.01); C07C 237/42 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A compound selected from the group consisting of:

OG Complex Work Unit Chemistry
or an optically pure stereoisomer or pharmaceutically acceptable salt thereof.