	US 12,240,814 B2
	1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use
Lisa Patel, London (GB); and Stephen Allan Smith, Bishops Stortford (GB)
Assigned to Istesso Therapeutics Limited, London (GB)
Filed by Istesso Therapeutics Limited, London (GB)
Filed on Oct. 24, 2023, as Appl. No. 18/493,017.
Application 18/493,017 is a division of application No. 17/265,929, granted, now 11,834,414, previously published as PCT/EP2019/071917, filed on Aug. 15, 2019.
Claims priority of application No. 1813312 (GB), filed on Aug. 15, 2018.
Prior Publication US 2024/0182418 A1, Jun. 6, 2024
Int. Cl. C07D 213/61 (2006.01); C07C 317/22 (2006.01); C07C 317/36 (2006.01); C07D 213/06 (2006.01)

CPC C07D 213/61 (2013.01) [C07C 317/22 (2013.01); C07C 317/36 (2013.01); C07D 213/06 (2013.01)]

30 Claims

1. A method of treating inflammatory arthritis in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound of the following formula:

or a pharmaceutically acceptable salt thereof,

wherein:

═X— is independently —CH═ or —N═;

—R¹is independently —H or —R^1X;

—R^1Xis independently —F, —Cl, —R^1C, —R^1F, or —CN;

—R^1Cis independently saturated linear or branched C_1-3alkyl;

—R^1Fis independently saturated linear or branched C_1-3fluoroalkyl;

—R²is independently —H or —R^2X;

—R^2Xis independently —F, —Cl, —R^2C, —R^2F, or —CN;

—R^2Cis independently saturated linear or branched C_1-3alkyl;

—R^2Fis independently saturated linear or branched C_1-3fluoroalkyl;

—R³is independently —H or —R^3X;

—R^3Xis independently —F, —Cl, —R^3C, —R^3F, or —CN;

—R^3Cis independently saturated linear or branched C_1-3alkyl;

—R^3Fis independently saturated linear or branched C_1-3fluoroalkyl;

—R⁴is independently —H or —R^4X;

—R^4Xis independently —F, —Cl, —R^4C, —R^4F, or —CN;

—R^4Cis independently saturated linear or branched C_1-3alkyl;

—R^4Fis independently saturated linear or branched C_1-3fluoroalkyl;

—R⁵is independently —H or —R^5X;

—R^5Xis independently —F, —R^5C, or —R^5F;

—R^5Cis independently saturated linear or branched C_1-3alkyl;

—R^5Fis independently saturated linear or branched C_1-3fluoroalkyl;

—R⁶is independently —H or —R^6X;

—R^6Xis independently —F, —R^6C, or —R^6F;

R^6Cis independently saturated linear or branched C_1-3alkyl; and

—R^6Fis independently saturated linear or branched C_1-3fluoroalkyl;

or —R⁵and —R⁶, taken together with the carbon atom to which they are attached, form saturated C_3-6cycloalkyl.