US 12,239,980 B2
Implementing barriers for controlled environments during sample processing and detection
Nathan Beckett, Oakland, CA (US); and Nathan Caswell, Sunnyvale, CA (US)
Assigned to Ultima Genomics, Inc., Fremont, CA (US)
Filed by Ultima Genomics, Inc., Newark, CA (US)
Filed on Jun. 2, 2021, as Appl. No. 17/336,377.
Application 17/336,377 is a continuation of application No. PCT/US2019/064916, filed on Dec. 6, 2019.
Application PCT/US2019/064916 is a continuation in part of application No. 16/665,540, filed on Oct. 28, 2019, granted, now 11,396,015.
Application PCT/US2019/064916 is a continuation in part of application No. 16/665,559, filed on Oct. 28, 2019, granted, now 11,648,554.
Application PCT/US2019/064916 is a continuation in part of application No. 16/440,026, filed on Jun. 13, 2019, granted, now 10,512,911, issued on Dec. 24, 2019.
Claims priority of provisional application 62/776,866, filed on Dec. 7, 2018.
Prior Publication US 2021/0354126 A1, Nov. 18, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. B01L 3/00 (2006.01); G01N 7/02 (2006.01)
CPC B01L 3/50273 (2013.01) [B01L 3/502715 (2013.01); G01N 7/02 (2013.01)] 20 Claims
 
1. A system for processing or analyzing an analyte, comprising: a chamber and a lid, wherein said chamber comprises an internal region and a substrate, wherein said analyte is immobilized adjacent to said substrate, wherein said lid is disposed adjacent to and not in mechanical contact with said chamber; and an environmental unit to maintain a first local environment and a second local environment within said internal region while said lid is not in mechanical contact with said chamber and during movement of said substrate within said chamber, wherein said environmental unit maintains (i) said first local environment at a first temperature or first temperature range, and (ii) said second local environment at a second temperature or second temperature range,
wherein said first local environment is disposed above said second local environment, and wherein said first local environment is at or in proximity to said lid,
wherein said second local environment is disposed at or near a surface of said substrate, and
wherein said first temperature or first temperature range is higher than said second temperature or second temperature range.