US 12,239,977 B2
Porous substrate-based microfluidic devices
Nityanand Kumawat, Abu Dhabi (AE); Soja Saghar Soman, Abu Dhabi (AE); Vijayavenkataraman Sanjairaj, Abu Dhabi (AE); and Sunil Kumar, Abu Dhabi (AE)
Assigned to New York University in Abu Dhabi Corporation, Abu Dhabi (AE)
Filed by New York University in Abu Dhabi Corporation, Abu Dhabi (AE)
Filed on Nov. 2, 2022, as Appl. No. 18/052,015.
Claims priority of provisional application 63/274,697, filed on Nov. 2, 2021.
Prior Publication US 2023/0285960 A1, Sep. 14, 2023
Int. Cl. B01L 3/00 (2006.01); B32B 27/30 (2006.01); B32B 27/36 (2006.01); B32B 37/06 (2006.01); B32B 37/12 (2006.01); B32B 37/18 (2006.01)
CPC B01L 3/502707 (2013.01) [B32B 27/306 (2013.01); B32B 27/36 (2013.01); B32B 37/06 (2013.01); B32B 37/12 (2013.01); B32B 37/182 (2013.01); B32B 2250/05 (2013.01); B32B 2250/40 (2013.01); B32B 2307/728 (2013.01); B32B 2309/025 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method of manufacturing a microfluidic analytical device comprising:
providing a top lamination layer and a bottom lamination layer, wherein each of the top lamination layer and the bottom lamination layer comprises an outer layer and an inner layer;
cutting out one or more channel spaces from the at least one of the top lamination layer and the bottom lamination layer;
positioning at least one porous middle layer between the top lamination layer and the bottom lamination layer, such that each of the two inner layers face the at least one porous middle layer;
wherein the at least one porous middle layer contacts an entire surface of the inner layers of the top lamination layer and the bottom lamination layer;
subjecting the top lamination layer and the bottom lamination layer to a process;
wherein the process creates one or more hydrophilic channels in the at least one porous middle layer within the channel spaces;
wherein the process impregnates the at least one porous middle layer with a portion of the inner layers in the region around the channel spaces, thereby creating hydrophobic barriers surrounding each of the one or more hydrophilic channels.