US 12,239,833 B2
Adaptive closed-loop DBS stimulation control
Ingrid Van Welie, Newton, MA (US); and Girish Rughoobur, Cambridge, MA (US)
Assigned to Neural Dynamics Technologies Inc., , MA (US)
Filed by Neural Dynamics Technologies Inc., Boston, MA (US)
Filed on Mar. 4, 2024, as Appl. No. 18/594,082.
Application 18/594,082 is a continuation of application No. PCT/US2024/017059, filed on Feb. 23, 2024.
Claims priority of provisional application 63/447,996, filed on Feb. 24, 2023.
Prior Publication US 2024/0285937 A1, Aug. 29, 2024
Int. Cl. A61N 1/05 (2006.01); A61B 5/00 (2006.01); A61B 5/293 (2021.01); A61B 5/304 (2021.01); A61B 5/31 (2021.01); A61N 1/36 (2006.01); A61N 1/378 (2006.01)
CPC A61N 1/0534 (2013.01) [A61B 5/0031 (2013.01); A61B 5/293 (2021.01); A61B 5/304 (2021.01); A61B 5/31 (2021.01); A61B 5/7225 (2013.01); A61N 1/36132 (2013.01); A61N 1/36139 (2013.01); A61N 1/36146 (2013.01); A61N 1/3787 (2013.01); A61B 2560/0219 (2013.01); A61B 2562/125 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A deep brain stimulation system, comprising:
a neural probe configured for placement within a brain;
at least one signal lead extending from the neural probe;
a sensing assembly included on the neural probe, where the sensing assembly includes at least one sensing micro-electrode positioned on the neural probe and a plurality of stimulation electrodes positioned on the neural probe, wherein the at least one sensing micro-electrode has a surface area of between 100 and 300 square microns; and
at least one processor assembly configured to:
receive, via the at least one signal lead, at least one sense signal generated in response to interaction between the at least one sensing micro-electrode and one or more electrical signals generated by a single neuron in a deep brain region of the brain, such that the at least one sensing micro-electrode provides single-neuron sensing resolution of action potentials in the deep brain region;
determine a target stimulation pattern based on at least one characteristic of the at least one sense signal; and
cause a signal generator to deliver, via the at least one signal lead, one or more stimulation signals to a set of stimulation electrodes among the plurality of stimulating electrodes to activate the set of stimulation electrodes according to the target stimulation pattern, wherein at least one of the set of stimulation electrodes is configured to stimulate the deep brain region with single-neuron resolution.