US 12,239,807 B2
Intravesical drug delivery devices and methods including elastic polymer-drug matrix systems
Heejin Lee, Bedford, MA (US); and Karen Daniel, Newton, MA (US)
Assigned to TARIS Biomedical LLC, Lexington, MA (US)
Filed by TARIS Biomedical LLC, Lexington, MA (US)
Filed on Aug. 10, 2020, as Appl. No. 16/989,208.
Application 16/989,208 is a division of application No. 15/321,110, granted, now 10,737,078, previously published as PCT/US2015/037887, filed on Jun. 26, 2015.
Claims priority of provisional application 62/017,775, filed on Jun. 26, 2014.
Prior Publication US 2020/0368508 A1, Nov. 26, 2020
Int. Cl. A61M 31/00 (2006.01); A61K 9/00 (2006.01); A61M 25/00 (2006.01)
CPC A61M 31/002 (2013.01) [A61K 9/0034 (2013.01); A61M 25/0009 (2013.01); A61M 2205/0216 (2013.01); A61M 2207/00 (2013.01); A61M 2210/1085 (2013.01)] 14 Claims
OG exemplary drawing
 
1. An intravesical drug delivery device comprising:
an elongated body formed of a matrix system of a drug dispersed in a silicone, the elongated body having a first end, an opposed second end, and an intermediate portion between the first and second ends; and
an elastic retention frame associated with the elongated body and effective to bias the elongated body into a coiled retention shape,
wherein the elastic retention frame is disposed within a lumen sealed at its ends and defined by an annular tube which is located within the matrix system, the lumen extending in a direction from the first end to the second end.
 
7. An intravesical drug delivery device comprising:
an elongated body formed of a matrix system of a drug dispersed in a silicone, the elongated body having a first end, an opposed second end, and an intermediate portion between the first and second ends;
an elastic retention frame associated with the elongated body and effective to bias the elongated body into a coiled retention shape; and
an outer wall layer that covers at least the intermediate portion, wherein the outer wall layer comprises a water- and drug-permeable polymeric material,
wherein the elastic retention frame comprises a nitinol wire or other superelastic wire,
wherein the nitinol wire or other superelastic wire is disposed within a lumen which is adjacent to the elongated body, the lumen extending in a direction from the first end to the second end and being defined by an annular tube which is formed of the water- and drug-permeable polymeric material.
 
8. An intravesical drug delivery device comprising:
an elongated body formed of a matrix system of a drug dispersed in a biocompatible polymer, the elongated body having a first end, an opposed second end, and an intermediate portion between the first and second ends; and
an elastic retention frame associated with the elongated body and effective to bias the elongated body into a coiled retention shape,
wherein the matrix system extends from the first end to the second end, and
wherein the elastic retention frame is disposed within a lumen sealed at its ends and defined by an annular tube which is located within the matrix system, the lumen extending in a direction from the first end to the second end.
 
10. An intravesical drug delivery device comprising:
an elongated body formed of a matrix system of a drug dispersed in a non-bioerodible, biocompatible polymer, the elongated body having a first end and an opposed second end wherein the matrix system extends continuously between the first end and the second end,
wherein the polymer of the matrix system biases the device in a retention shape, such that the device is elastically deformable between a relatively straightened shape suited for insertion of the device through the urethra and into the urinary bladder of a patient and the retention shape which is suited to retain the device within the urinary bladder.