US 12,239,763 B2
Peptides and antibodies for the removal of biofilms
Lauren O. Bakaletz, Hilliard, OH (US); and Steven D. Goodman, Hilliard, OH (US)
Assigned to RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US)
Filed by RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US)
Filed on Apr. 28, 2023, as Appl. No. 18/141,270.
Application 18/141,270 is a continuation of application No. 17/150,731, filed on Jan. 15, 2021, granted, now 11,684,673.
Application 17/150,731 is a continuation of application No. 15/744,713, granted, now 10,940,204, issued on Mar. 9, 2021, previously published as PCT/US2016/045032, filed on Aug. 1, 2016.
Claims priority of provisional application 62/199,957, filed on Jul. 31, 2015.
Claims priority of provisional application 62/387,562, filed on Dec. 23, 2015.
Claims priority of provisional application 62/361,400, filed on Jul. 12, 2016.
Prior Publication US 2024/0075138 A1, Mar. 7, 2024
Int. Cl. A61L 27/54 (2006.01); A61K 8/64 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 39/395 (2006.01); A61K 39/40 (2006.01); A61L 29/16 (2006.01); A61P 31/04 (2006.01); A61Q 11/00 (2006.01); A61Q 17/00 (2006.01); C07K 16/12 (2006.01); C07K 16/18 (2006.01); C12N 15/62 (2006.01)
CPC A61L 27/54 (2013.01) [A61K 8/64 (2013.01); A61K 39/12 (2013.01); A61K 39/395 (2013.01); A61K 39/40 (2013.01); A61L 29/16 (2013.01); A61P 31/04 (2018.01); A61Q 11/00 (2013.01); A61Q 17/005 (2013.01); C07K 16/12 (2013.01); C07K 16/1217 (2013.01); C07K 16/1232 (2013.01); C07K 16/1242 (2013.01); C07K 16/1271 (2013.01); C07K 16/1275 (2013.01); C07K 16/18 (2013.01); C12N 15/62 (2013.01); A61K 2039/507 (2013.01); A61L 2300/404 (2013.01); C07K 2317/34 (2013.01); C07K 2317/76 (2013.01)] 18 Claims
 
1. A composition comprising one or more of a preservative, an adjuvant, or a stabilizer; and an isolated polynucleotide encoding one or more polypeptides selected from:
(i)
SEQ ID NO. 13 
a polypeptide consisting of (RPGRNPKTGDVVPVSARRVV);
 
(ii)
SEQ ID NO. 16 
a polypeptide consisting of (RGFGSFSLHHRQPRLGRNPK); 
or
 
(iii)
SEQ ID NO. 17 
a polypeptide consisting of (FSLHHRQPRLGRNPKTGDSV).