CPC A61L 27/46 (2013.01) [A61L 27/52 (2013.01); A61L 27/58 (2013.01); A61L 2400/06 (2013.01); A61L 2430/02 (2013.01); A61L 2430/12 (2013.01)] | 21 Claims |
1. A composition for forming a bone cement comprising:
a. a reactive apatite forming composition in the form of a plurality of particles that will together react to form an apatitic calcium phosphate due to cementitious hardening in the presence of a hydrating fluid, wherein the reactive apatite forming composition comprises a mixture of discrete particles and wherein each particle of the mixture consists of monocalcium phosphate monohydrate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, dicalcium phosphate dihydrate, octacalcium phosphate, alpha-tricalcium phosphate, beta-tricalcium phosphate, amorphous calcium phosphate, calcium deficient hydroxyapatite, hydroxyapatite, tetracalcium phosphate, CaSO4, CaSO4·0.5H2O, CaSO4·2H2O, CaO, Ca(OH)2, CaCO3, or a mixture of two or more of the foregoing;
b. particles of a water soluble polymer; and
c. particles of a swelling additive comprising non-enzymatically processed, acid soluble collagen;
wherein, if contacted with a suitable amount of a hydrating fluid, the composition forms a hydrated precursor within which the swelling additive is suspended as a particle and thereafter hardens to an apatitic calcium phosphate via cementitious hardening of the reactive apatite forming composition.
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