US 12,239,762 B2
Settable bone void filler
Andrew Fallis, Springfield, PA (US); Steven Leonhardt, Spring City, PA (US); Justin Kontra, Downingtown, PA (US); Rakesh Batish, Phoenixville, PA (US); and Timothy Ringeisen, Exton, PA (US)
Assigned to DSM IP ASSETS B.V., Heerlen (NL)
Filed by DSM IP Assets B.V., Heerlen (NL)
Filed on Jun. 21, 2022, as Appl. No. 17/845,141.
Application 17/845,141 is a continuation of application No. 16/305,117, granted, now 11,395,864, previously published as PCT/US2017/037064, filed on Jun. 12, 2017.
Claims priority of provisional application 62/348,575, filed on Jun. 10, 2016.
Prior Publication US 2022/0395613 A1, Dec. 15, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/46 (2006.01); A61L 27/52 (2006.01); A61L 27/58 (2006.01)
CPC A61L 27/46 (2013.01) [A61L 27/52 (2013.01); A61L 27/58 (2013.01); A61L 2400/06 (2013.01); A61L 2430/02 (2013.01); A61L 2430/12 (2013.01)] 21 Claims
 
1. A composition for forming a bone cement comprising:
a. a reactive apatite forming composition in the form of a plurality of particles that will together react to form an apatitic calcium phosphate due to cementitious hardening in the presence of a hydrating fluid, wherein the reactive apatite forming composition comprises a mixture of discrete particles and wherein each particle of the mixture consists of monocalcium phosphate monohydrate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, dicalcium phosphate dihydrate, octacalcium phosphate, alpha-tricalcium phosphate, beta-tricalcium phosphate, amorphous calcium phosphate, calcium deficient hydroxyapatite, hydroxyapatite, tetracalcium phosphate, CaSO4, CaSO4·0.5H2O, CaSO4·2H2O, CaO, Ca(OH)2, CaCO3, or a mixture of two or more of the foregoing;
b. particles of a water soluble polymer; and
c. particles of a swelling additive comprising non-enzymatically processed, acid soluble collagen;
wherein, if contacted with a suitable amount of a hydrating fluid, the composition forms a hydrated precursor within which the swelling additive is suspended as a particle and thereafter hardens to an apatitic calcium phosphate via cementitious hardening of the reactive apatite forming composition.