US 12,239,758 B2
Adhesive device for biomedical applications and methods of use thereof
Paul Santerre, Toronto (CA); Eli Sone, Toronto (CA); Michael Floros, Toronto (CA); Jeffrey Fialkov, Toronto (CA); and Cari Whyne, Toronto (CA)
Assigned to THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, Toronto (CA); and SUNNYBROOK HEALTH SCIENCES CENTRE, Toronto (CA)
Appl. No. 17/787,552
Filed by THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, Toronto (CA); and SUNNYBROOK HEALTH SCIENCES CENTRE, Toronto (CA)
PCT Filed Dec. 21, 2020, PCT No. PCT/CA2020/051781
§ 371(c)(1), (2) Date Jun. 20, 2022,
PCT Pub. No. WO2021/119853, PCT Pub. Date Jun. 24, 2021.
Claims priority of provisional application 62/951,810, filed on Dec. 20, 2019.
Prior Publication US 2023/0012485 A1, Jan. 19, 2023
Int. Cl. A61L 24/04 (2006.01); A61L 24/00 (2006.01)
CPC A61L 24/046 (2013.01) [A61L 24/0036 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A device comprising:
a support;
and
a water insoluble adhesive on at least one bonding site on a surface of the support, the adhesive comprising:
a compound of structure 1

OG Complex Work Unit Chemistry
wherein
the compound is water insoluble;
the compound has a Tg lower than 25° C.;
B is a branched or unbranched oligomer derived from a polyester, polyether, polyalkylene glycol, polysilicone or polycarbonate with a MW<10,000 g/mol;
Linker L is an urethane, urea bond, or amide bond;
Linker L′ is an urethane or urea bond;
A is a chain extender of Mw s 3000 g/mol comprising substituted or unsubstituted alkyl, cycloalkyl and/or aromatic groups;
W is a terminal adhesive selected from an adhesive benzene-1,2-diol derivative or an adhesive benzene-1,2,3-triol derivative;
m is 0 or 1; and
n is 0, 1, 2, 3 or 4; or
a cross-linked polymer produced by cross-linking compounds of structure 1.