	US 12,239,741 B1
	Hydroxyapatite-enclosed zinc phosphate nanocomposite
Ahmed A Allam, Riyadh (SA); Hassan A. Rudayni, Riyadh (SA); Mostafa R. Abukhadra, Riyadh (SA); and Islam R. Sayed, Riyadh (SA)
Assigned to IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY, Riyadh (SA)
Filed by IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY, Riyadh (SA)
Filed on Oct. 15, 2024, as Appl. No. 18/915,867.
Application 18/915,867 is a continuation of application No. 18/640,787, filed on Apr. 19, 2024, granted, now 12,151,027.
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/20 (2006.01); A61K 31/555 (2006.01); B82Y 5/00 (2011.01)

CPC A61K 9/2072 (2013.01) [A61K 9/2009 (2013.01); A61K 9/205 (2013.01); A61K 31/555 (2013.01); B82Y 5/00 (2013.01)]

20 Claims

1. A drug delivery system, comprising a nanocomposite,

wherein the nanocomposite comprises:

a zinc phosphate core;

a hydroxyapatite shell; and

chitosan;

wherein the hydroxyapatite shell at least completely encloses the zinc phosphate core,

wherein the chitosan at least partially wraps around the hydroxyapatite shell,

wherein the chitosan interacts with the hydroxyapatite shell through hydrogen bonding, and

wherein the nanocomposite is loaded with oxaliplatin to form the drug delivery system.