US 12,239,721 B2
Polydopamine decorated tobacco mosaic theranostic virus nanoparticles
Nicole F. Steinmetz, San Diego, CA (US); and He Hu, Cleveland, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed on Dec. 15, 2022, as Appl. No. 18/081,916.
Application 18/081,916 is a continuation of application No. 17/129,490, filed on Dec. 21, 2020, granted, now 11,529,430, issued on Dec. 20, 2022.
Claims priority of provisional application 62/951,129, filed on Dec. 20, 2019.
Prior Publication US 2023/0201381 A1, Jun. 29, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 49/18 (2006.01); A61K 41/00 (2020.01); A61K 49/10 (2006.01)
CPC A61K 49/1896 (2013.01) [A61K 41/0052 (2013.01); A61K 49/108 (2013.01)] 20 Claims
 
1. A nanoparticle comprising:
a rod-shaped plant virus like particle (VLP), one or more gadolinium contrast agents conjugated to an interior surface of the VLP, and a layer of polydopamine (PDA) coated over a portion of the exterior surface of the VLP, wherein the VLP conjugated to one or more gadolinium contrast agents is coated with an amount of PDA effective to inhibit aggregation with one or more additional PDA coated VLPs.