US 12,239,713 B2
Degradable polyethylene glycol conjugate
Hiroki Yoshioka, Kanagawa (JP); Masaki Kamiya, Kawasaki (JP); Yuji Yamamoto, Kawasaki (JP); Midori Hirai, Kawasaki (JP); Akiko Sasaki, Kawasaki (JP); Nobuhiro Nishiyama, Tokyo (JP); Makoto Matsui, Tokyo (JP); Hiroyasu Takemoto, Tokyo (JP); Kazuki Miyauchi, Tokyo (JP); Takahiro Nomoto, Tokyo (JP); and Keishiro Tomoda, Tokyo (JP)
Assigned to NOF CORPORATION, Tokyo (JP); and TOKYO INSTITUTE OF TECHNOLOGY, Tokyo (JP)
Appl. No. 17/042,039
Filed by NOF CORPORATION, Tokyo (JP); and TOKYO INSTITUTE OF TECHNOLOGY, Tokyo (JP)
PCT Filed Mar. 29, 2019, PCT No. PCT/JP2019/014245
§ 371(c)(1), (2) Date Sep. 25, 2020,
PCT Pub. No. WO2019/189853, PCT Pub. Date Oct. 3, 2019.
Claims priority of application No. 2018-064306 (JP), filed on Mar. 29, 2018.
Prior Publication US 2021/0023231 A1, Jan. 28, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/60 (2017.01); A61K 38/19 (2006.01); A61K 38/23 (2006.01); A61K 38/27 (2006.01); C07K 5/103 (2006.01); C07K 7/06 (2006.01); C07K 19/00 (2006.01); C08G 65/333 (2006.01)
CPC A61K 47/60 (2017.08) [A61K 38/193 (2013.01); A61K 38/23 (2013.01); A61K 38/27 (2013.01); C07K 5/1008 (2013.01); C07K 7/06 (2013.01); C07K 19/00 (2013.01); C08G 65/33396 (2013.01)] 14 Claims
 
1. A bio-related substance bonded to a degradable polyethylene glycol derivative, and represented by formula (A):

OG Complex Work Unit Chemistry
wherein D is the bio-related substance, and wherein

OG Complex Work Unit Chemistry
is ME-200GLFG(L)-200PA, ME-200GGG-200PA, ME-200GF-200PA, ME-200GAV-200PA, ME-200GFGG-200PA, or LY-(ME-100GLFG(L)-100)2-PA.