	US 12,239,700 B2
	Identification of variable influenza residues and uses thereof
Darrell O. Ricke, Winchester, MA (US)
Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US)
Filed by MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US)
Filed on Mar. 21, 2023, as Appl. No. 18/187,133.
Application 18/187,133 is a division of application No. 17/186,851, filed on Feb. 26, 2021, granted, now 11,642,407.
Claims priority of provisional application 62/983,519, filed on Feb. 28, 2020.
Prior Publication US 2024/0207386 A1, Jun. 27, 2024
Int. Cl. A61K 39/145 (2006.01); A61K 39/12 (2006.01); A61K 31/16 (2006.01)

CPC A61K 39/145 (2013.01) [A61K 39/12 (2013.01); A61K 31/16 (2013.01)]

9 Claims

1. An immunogenic composition comprising one or more polypeptides comprising an amino acid sequence at least 80% identical to the amino acid sequence of SEQ ID NO:3, wherein the one or more polypeptides each comprise mutations to alanine or glycine at each of residues 238, 239, 241, 242, and 243 relative to the amino acid sequence of SEQ ID NO:3.