US 12,239,694 B2
Methods and compositions for improved cognition
Dena Dubal, Oakland, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Jun. 28, 2023, as Appl. No. 18/215,276.
Application 18/215,276 is a continuation of application No. 17/095,673, filed on Nov. 11, 2020, granted, now 11,738,070.
Application 17/095,673 is a continuation of application No. 16/751,108, filed on Jan. 23, 2020, granted, now 10,864,256, issued on Dec. 15, 2020.
Application 16/751,108 is a continuation of application No. 15/548,306, granted, now 10,632,180, issued on Apr. 28, 2020, previously published as PCT/US2016/016842, filed on Feb. 5, 2016.
Claims priority of provisional application 62/113,300, filed on Feb. 6, 2015.
Prior Publication US 2024/0108698 A1, Apr. 4, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/47 (2006.01); A61K 38/00 (2006.01); A61P 25/28 (2006.01); C12N 9/24 (2006.01)
CPC A61K 38/47 (2013.01) [A61P 25/28 (2018.01); C12N 9/2402 (2013.01); C12Y 302/01031 (2013.01); A61K 38/00 (2013.01)] 13 Claims
 
1. A method for improving cognitive function in an individual in need thereof, comprising administering systemically or peripherally to the individual an effective amount of a polypeptide that includes an amino acid sequence that is at least 95% identical to the sequence of the KL1 domain contained in SEQ ID NO: 1, with the proviso that the polypeptide is not a fibroblast growth factor (FGF) fusion protein.