| CPC A61K 36/65 (2013.01) [A61K 36/39 (2013.01); A61P 13/12 (2018.01); A61K 2236/15 (2013.01); A61K 2236/17 (2013.01); A61K 2236/331 (2013.01); A61K 2236/51 (2013.01); A61K 2236/53 (2013.01)] | 5 Claims |
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1. A peony stamen-dodder composite for treating nephritis, wherein raw materials of the peony stamen-dodder composite comprise 10-18 parts by weight of a peony stamen and 5-12 parts by weight of a dodder; and the peony stamen-dodder composite is prepared through steps of:
step (1) subjecting the peony stamen to desensitization, impregnation with a first saline and drying, and subjecting the dodder to impregnation with a second saline and baking; and
step (2) crushing a treated peony stamen obtained in step (1), and crushing a treated dodder obtained in step (1); impregnating a crushed peony stamen and a crushed dodder with warm water followed by a first ultrasonic treatment and filtration to obtain a first filtrate and a filter residue; dispersing the filter residue in water followed by a second ultrasonic treatment and filtration to obtain a second filtrate; and combining the first filtrate with the second filtrate followed by vacuum concentration to obtain the peony stamen-dodder composite;
wherein in step (1), the desensitization is performed at 120° C. for 1-3 min, or performed by microwave-assisted desensitization at a power of 3,000-5,000 W and a temperature of 65-80° C. for 1-3 min; a thickness of the peony stamen is 3-6 mm; the drying is performed at 55-65° C. for 4.5-5.5 h; the baking is performed at 75-85° C. for 7.5-8.5 h; the first saline and the second saline both have a concentration of 1.2-1.8 wt. %; a weight of the first saline is 1-2 times a weight of the peony stamen; a weight of the second saline is 0.25-2 times the weight of the peony stamen; and the impregnation of the peony stamen is performed for 8-15 min, and the impregnation of the dodder is performed for 15-25 min;
in step (2), a weight of the warm water is 19-21 times a total weight of the peony stamen and the dodder, a temperature of the warm water is 65-75° C., and the crushed peony stamen and the crushed dodder are impregnated in the warm water for 1.5-2.5 h;
in step (2), the first ultrasonic treatment is carried out for 25-35 min, and the second ultrasonic treatment is carried out for 55-65 min; a weight of the water for dispersing the filter residue is 14-16 times a total weight of the peony stamen and the dodder; and
in step (2), a temperature of the vacuum concentration does not exceed 70° C., and the vacuum concentration is performed such that a weight of a concentrated product is 7.9-8.1 times the total weight of the peony stamen and the dodder.
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