US 12,239,681 B2
Formulations and methods for skin care
Apostolos Pappas, Norwood, MA (US); and Olga Ilnytska, Norwood, MA (US)
Assigned to AMILYFE, LLC, Norwood, MA (US)
Filed by AMILYFE, LLC, Norwood, MA (US)
Filed on Jul. 3, 2024, as Appl. No. 18/764,014.
Application 18/764,014 is a continuation of application No. PCT/US2022/082663, filed on Dec. 30, 2022.
Claims priority of provisional application 63/296,033, filed on Jan. 3, 2022.
Prior Publication US 2024/0350571 A1, Oct. 24, 2024
Int. Cl. A61K 36/00 (2006.01); A61K 8/44 (2006.01); A61K 8/49 (2006.01); A61K 8/67 (2006.01); A61K 8/9789 (2017.01); A61K 9/00 (2006.01); A61K 31/07 (2006.01); A61K 31/11 (2006.01); A61K 31/198 (2006.01); A61K 31/203 (2006.01); A61K 31/232 (2006.01); A61K 31/405 (2006.01); A61K 36/32 (2006.01); A61K 36/324 (2006.01); A61K 45/06 (2006.01); A61K 47/24 (2006.01); A61K 47/38 (2006.01); A61Q 19/00 (2006.01)
CPC A61K 36/324 (2013.01) [A61K 8/44 (2013.01); A61K 8/442 (2013.01); A61K 8/492 (2013.01); A61K 8/671 (2013.01); A61K 8/9789 (2017.08); A61K 9/00 (2013.01); A61K 31/07 (2013.01); A61K 31/11 (2013.01); A61K 31/198 (2013.01); A61K 31/203 (2013.01); A61K 31/232 (2013.01); A61K 31/405 (2013.01); A61K 36/32 (2013.01); A61K 45/06 (2013.01); A61K 47/24 (2013.01); A61K 47/38 (2013.01); A61Q 19/00 (2013.01); A61K 2800/10 (2013.01)] 13 Claims
 
1. A topical formulation, comprising:
(a) as free amino acids, a therapeutically effective amount consisting essentially of a combination of glutamine, glycine, alanine, and serine, or salts thereof,
wherein each free amino acid has a ratio to each of the other free amino acids of: 1:100 or greater; and
(b) a therapeutically effective amount of a plant extract comprising Boswellia extract,
wherein the therapeutically effective amount of the combination and the therapeutically effective amount of the plant extract improve barrier integrity of skin cells when tested by a method detecting EGF expression and determining that EGF is upregulated by a 1.5-40 average fold change of formulation treated as compared to untreated skin,
wherein the therapeutically effective amount of the combination and the therapeutically effective amount of plant extract improve barrier integrity of the skin and/or skin barrier repair.