	US 12,239,676 B2
	Synbiotic composition for improving immune response and antioxidant capacity during aging and a process for the preparation thereof
Rohit Sharma, Pradesh (IN); Mahesh Gupta, Pradesh (IN); Madhu Kumari, Pradesh (IM); Ashu Gulati, Pradesh (IN); and Yogendra S. Padwad, Pradesh (IN)
Assigned to COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH, New Delhi (IN)
Filed by COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH, New Delhi (IN)
Filed on Jul. 7, 2023, as Appl. No. 18/219,581.
Application 18/219,581 is a division of application No. 17/260,052, abandoned, previously published as PCT/IN2019/050515, filed on Jul. 11, 2019.
Claims priority of application No. 201811026239 (IN), filed on Jul. 13, 2018.
Prior Publication US 2023/0346860 A1, Nov. 2, 2023
Int. Cl. A61K 35/747 (2015.01); A61K 36/82 (2006.01); C12N 1/20 (2006.01); C12R 1/225 (2006.01)

CPC A61K 35/747 (2013.01) [A61K 36/82 (2013.01); C12N 1/20 (2013.01); C12R 2001/225 (2021.05)]

9 Claims

1. A method of improving immune response and antioxidant capacity of an animal subject, the method comprising:

administering a synbiotic composition to the animal subject, wherein the synbiotic composition comprises:

(i) a probiotic micro-organism Lactobacillus fermentum MCC 3160, and

(ii) a prebiotic epigallocatechin gallate (EGCG) isolated from Kangra green tea leaves from Camellia sinensis,

wherein

improving immune response in the animal subject comprises an increase in the production of Th1 and Th2 cytokines, and

improving antioxidant capacity in the animal subject comprises activation of Nrf2 transcription factor.