US 12,239,661 B2
Methods and compositions for treating undesired implanted tissue filler
Wojciech Danysz, Nidderau (DE); Peter Kreymerman, Raleigh, NC (US); and Patrick Plitt, Bad Homburg (DE)
Assigned to Merz North America, Inc., Raleigh, NC (US)
Appl. No. 17/612,159
Filed by MERZ NORTH AMERICA, INC., Raleigh, NC (US)
PCT Filed Jun. 3, 2020, PCT No. PCT/US2020/035881
§ 371(c)(1), (2) Date Nov. 17, 2021,
PCT Pub. No. WO2020/247469, PCT Pub. Date Dec. 10, 2020.
Claims priority of provisional application 62/949,381, filed on Dec. 17, 2019.
Claims priority of provisional application 62/858,316, filed on Jun. 6, 2019.
Prior Publication US 2022/0218739 A1, Jul. 14, 2022
Int. Cl. A61K 33/14 (2006.01); A61K 8/19 (2006.01); A61K 8/20 (2006.01); A61K 8/23 (2006.01); A61K 8/24 (2006.01); A61K 8/34 (2006.01); A61K 8/36 (2006.01); A61K 8/365 (2006.01); A61K 8/60 (2006.01); A61K 9/00 (2006.01); A61L 27/12 (2006.01); A61P 17/00 (2006.01); A61Q 19/08 (2006.01)
CPC A61K 33/14 (2013.01) [A61K 8/19 (2013.01); A61K 8/20 (2013.01); A61K 8/23 (2013.01); A61K 8/24 (2013.01); A61K 8/345 (2013.01); A61K 8/36 (2013.01); A61K 8/365 (2013.01); A61K 8/60 (2013.01); A61L 27/12 (2013.01); A61P 17/00 (2018.01); A61Q 19/08 (2013.01); A61K 9/0019 (2013.01); A61K 2800/884 (2013.01); A61K 2800/91 (2013.01)] 13 Claims
 
1. A method of treatment of a subject having undesired implanted tissue filler, which comprises administrating to the subject an effective amount of a hyperosmotic pharmaceutical composition consisting of an aqueous solution of NaCl by injection to a location containing the undesired amount or accumulation of implanted tissue filler.