US 12,239,657 B2
Iron compositions and methods of making and using them
Roshan James, Westerville, OH (US); Bindhu Madhavi Rayaprolu, Columbus, OH (US); Ting Zhang, Westerville, OH (US); and Meng Zhong, Westerville, OH (US)
Assigned to Vifor (International) AG, ST. Gallen (CH)
Filed by American Regent, Inc., Shirley, NY (US)
Filed on Aug. 25, 2022, as Appl. No. 17/895,738.
Claims priority of provisional application 63/237,765, filed on Aug. 27, 2021.
Prior Publication US 2023/0084291 A1, Mar. 16, 2023
Int. Cl. A61K 31/7135 (2006.01); A61K 9/00 (2006.01); A61K 47/02 (2006.01); A61K 47/22 (2006.01)
CPC A61K 31/7135 (2013.01) [A61K 9/0019 (2013.01); A61K 47/02 (2013.01); A61K 47/22 (2013.01)] 34 Claims
 
1. An injectable iron composition comprising water, an iron (III)-hydroxide-sucrose complex comprising 15 mg/mL to 30 mg/mL of sucrose complexed with iron (III)-hydroxide comprising 1 mg/mL to 2 mg/mL of elemental iron, the injectable iron composition having a total sucrose content of 57.5 mg/mL to 195 mg/mL, and a sodium compound in an amount of 0.07 mg/mL to 15 mg/mL of the injectable iron composition.