US 12,239,649 B2
Dietary fiber for treating patients suffering from methylmalonic acidemia and propionic acidemia
Mirjam Kuhn, Utrecht (NL); and Maryam Rakhshandehroo, Utrecht (NL)
Assigned to N.V. Nutricia, Zoetermeer (NL)
Appl. No. 17/281,598
Filed by N.V. Nutricia, Zoetermeer (NL)
PCT Filed Oct. 1, 2019, PCT No. PCT/NL2019/050657
§ 371(c)(1), (2) Date Mar. 31, 2021,
PCT Pub. No. WO2020/071909, PCT Pub. Date Apr. 9, 2020.
Claims priority of application No. 2021737 (NL), filed on Oct. 1, 2018.
Prior Publication US 2022/0040211 A1, Feb. 10, 2022
Int. Cl. A61K 31/702 (2006.01); A23L 33/00 (2016.01); A23L 33/12 (2016.01); A23L 33/125 (2016.01); A23L 33/135 (2016.01); A23L 33/155 (2016.01); A23L 33/16 (2016.01); A23L 33/175 (2016.01); A23L 33/18 (2016.01); A23L 33/22 (2016.01); A23L 33/24 (2016.01); A61K 31/202 (2006.01); A61K 31/59 (2006.01); A61K 31/715 (2006.01); A61K 31/717 (2006.01); A61K 31/718 (2006.01); A61K 31/733 (2006.01); A61K 31/736 (2006.01); A61K 33/06 (2006.01); A61K 35/745 (2015.01); A61K 35/747 (2015.01); A61P 7/08 (2006.01)
CPC A61K 31/702 (2013.01) [A23L 33/12 (2016.08); A23L 33/125 (2016.08); A23L 33/135 (2016.08); A23L 33/155 (2016.08); A23L 33/16 (2016.08); A23L 33/175 (2016.08); A23L 33/18 (2016.08); A23L 33/22 (2016.08); A23L 33/24 (2016.08); A23L 33/40 (2016.08); A61K 31/202 (2013.01); A61K 31/59 (2013.01); A61K 31/715 (2013.01); A61K 31/717 (2013.01); A61K 31/718 (2013.01); A61K 31/733 (2013.01); A61K 31/736 (2013.01); A61K 33/06 (2013.01); A61K 35/745 (2013.01); A61K 35/747 (2013.01); A61P 7/08 (2018.01); A23V 2002/00 (2013.01)] 14 Claims
 
1. A method for:
treating and/or reducing methylmalonic acidemia (MMA) and/or propionic acidemia (PA);
dietary management of MMA and/or PA; and/or
reducing gut flora induced production of propionic acid,
in a human subject having an age of at least 3 years and suffering from MMA or PA, wherein the method comprises administering to the human subject a composition comprising a fiber mixture, wherein the fiber mixture comprises galactooligosaccharides and 1.5-25 wt % resistant starch based on a total weight of the fiber mixture.