US 12,239,621 B2
Prevention of kidney injury induced by hemolytic reaction
Akihiko Saito, Niigata (JP); Sawako Goto, Niigata (JP); and Yoshiaki Hirayama, Tokyo (JP)
Assigned to Niigata University, Niigata (JP); and Denka Company Limited, Tokyo (JP)
Appl. No. 18/247,412
Filed by Niigata University, Niigata (JP); and Denka Company Limited, Tokyo (JP)
PCT Filed Mar. 8, 2022, PCT No. PCT/JP2022/010031
§ 371(c)(1), (2) Date Mar. 30, 2023,
PCT Pub. No. WO2022/191193, PCT Pub. Date Sep. 15, 2022.
Claims priority of application No. 2021-040083 (JP), filed on Mar. 12, 2021.
Prior Publication US 2023/0390229 A1, Dec. 7, 2023
Int. Cl. A61K 31/194 (2006.01); A61K 9/00 (2006.01); A61P 13/12 (2006.01)
CPC A61K 31/194 (2013.01) [A61K 9/0019 (2013.01); A61P 13/12 (2018.01)] 4 Claims
 
1. A method for inhibiting renal injuries induced by a hemolytic reaction, comprising administering to a subject in need thereof an inhibitor comprising cilastatin or a pharmaceutically acceptable salt thereof as an active component.