US 12,239,619 B2
Composition for inducing pili formation in bacterium of genus Bifidobacterium
Kanetada Shimizu, Kanagawa (JP); Ro Osawa, Hyogo (JP); Keita Nishiyama, Kanagawa (JP); Nobuhiko Okada, Kanagawa (JP); Nobuhiro Koyama, Kanagawa (JP); Takao Mukai, Kanagawa (JP); and Hiroshi Tomoda, Kanagawa (JP)
Assigned to Morinaga Milk Industry Co., Ltd., Tokyo (JP); National University Corporation Kobe University, Hyogo (JP); and The Kitasato Institute, Tokyo (JP)
Appl. No. 17/433,755
Filed by MORINAGA MILK INDUSTRY CO., LTD., Tokyo (JP); NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, Hyogo (JP); and THE KITASATO INSTITUTE, Tokyo (JP)
PCT Filed Feb. 28, 2020, PCT No. PCT/JP2020/008457
§ 371(c)(1), (2) Date Aug. 25, 2021,
PCT Pub. No. WO2020/175690, PCT Pub. Date Sep. 3, 2020.
Claims priority of application No. 2019-036309 (JP), filed on Feb. 28, 2019.
Prior Publication US 2022/0133665 A1, May 5, 2022
Int. Cl. A61K 31/192 (2006.01); A23K 10/18 (2016.01); A23K 20/111 (2016.01); A23L 2/52 (2006.01); A23L 33/135 (2016.01); A61K 35/00 (2006.01); A61K 35/742 (2015.01); A61K 35/745 (2015.01); A61P 1/00 (2006.01)
CPC A61K 31/192 (2013.01) [A23K 10/18 (2016.05); A23K 20/111 (2016.05); A23L 2/52 (2013.01); A23L 33/135 (2016.08); A61K 35/742 (2013.01); A61K 35/745 (2013.01); A61P 1/00 (2018.01); A23V 2002/00 (2013.01); A23V 2400/533 (2023.08); A61K 2035/115 (2013.01)] 2 Claims
OG exemplary drawing
 
1. A method for inducing pili formation in Bifidobacterium longum present in the intestines of an animal in need of increased pili formation in said bacterium,
wherein said method comprises orally administering to the animal 3-phenylpropionic acid and/or 3-(4-hydroxylphenyl) propionic acid, wherein said administering results in an increase in pili formation in the Bifidobacterium longum, and as a result of said increase, intestinal colonization in the animal by said bacterium is increased.