| CPC A61J 1/2013 (2015.05) [A61J 1/10 (2013.01); A61J 1/2037 (2015.05); A61J 1/2079 (2015.05); B01F 35/7137 (2022.01); B65B 3/003 (2013.01); A61J 2205/60 (2013.01)] | 20 Claims |

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1. A fluid flow coupling arrangement comprising:
a fluid supply manifold having a receptacle including an open end and an opposing end with a sidewall extending therebetween, the opposing end including a piercing member having a lumen in fluid communication with a fluid supply pathway, the manifold further including a disinfection flow path in fluid communication with the receptacle via a disinfection flow path access in the sidewall;
a cartridge including a port, the port including a set of sealing members in spaced relation to one another and each extending around an exterior surface of the port, the port further including a cover sealing an inlet opening of the port, the cartridge displaceable with respect to the manifold from a partially installed position to a spiked position, the port disposed at least partially within and sealing the receptacle in both the partially installed and spiked position, the piercing member being in fluid communication with the disinfection flow path and spaced apart from the cover when the cartridge is in the partially installed position and the piercing member isolated from the disinfection flow path and puncturing the cover when the cartridge is in the spiked position.
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