US 12,239,573 B2
Drug therapy delivery systems and methods
Peter J. Roeber, Oxford, PA (US); and Jeffrey C. Towler, Wilmington, DE (US)
Assigned to W. L. Gore & Associates, Inc., Newark, DE (US)
Appl. No. 17/272,609
Filed by W. L. Gore & Associates, Inc., Newark, DE (US)
PCT Filed Aug. 29, 2019, PCT No. PCT/US2019/048759
§ 371(c)(1), (2) Date Mar. 1, 2021,
PCT Pub. No. WO2020/047221, PCT Pub. Date Mar. 5, 2020.
Claims priority of provisional application 62/724,425, filed on Aug. 29, 2018.
Prior Publication US 2021/0346197 A1, Nov. 11, 2021
Int. Cl. A61F 9/00 (2006.01)
CPC A61F 9/0017 (2013.01) 26 Claims
OG exemplary drawing
 
1. An implantable delivery device for dispensing a medicament, the delivery device comprising: a first microporous layer including a plurality of pores sized to permit tissue ingrowth; a second microporous layer including a plurality of pores sized to permit tissue ingrowth; a third microporous layer coupled to the first microporous layer including a plurality of pores sized to resist tissue ingrowth; and a reservoir for receiving the medicament, the reservoir being defined between the third microporous layer and the second microporous layer, the reservoir having an inflated state when the reservoir is filled with a sufficient amount of the medicament and having a deflated state when the reservoir is devoid of the sufficient amount of the medicament, wherein when implanted in a body, uncoupled portions of the second and third microporous layers move toward each other when transitioning between the inflated and deflated states, such that the reservoir adopts a relatively flatter profile in the deflated state than in the inflated state, wherein at least a portion of the uncoupled portions of the second and third microporous layers are in contact when in the deflated state, wherein the third microporous layer is configured to meter a rate at which the medicament is eluted from the reservoir when the delivery device is implanted.