| CPC A61B 5/14865 (2013.01) [A61B 5/14532 (2013.01); A61B 2562/125 (2013.01)] | 39 Claims |

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1. An analyte sensor comprising: a working electrode including a working electrode layer having an elongate body comprising a proximal end and a distal end, the working electrode layer including a first active working electrode area, a second electrode portion, and at least one channel or well formed in the working electrode layer and electrically separating the first active working electrode area and the second electrode portion; and one or more additional electrodes, wherein the one or more additional electrodes comprise a counter electrode, a reference electrode, or both; and wherein the first active working electrode area comprises at least one sensing spot with at least one analyte responsive enzyme disposed thereupon and configured to generate a signal associated with an analyte of interest, wherein the second electrode portion is configured to reduce an overall interference to the signal attributed to one or more interferents.
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