	US 11,913,955 B2
	Methods for detecting cancers, and detecting reagent
Shohei Myoba, Ayase (JP); and Norihisa Ohtake, Ayase (JP)
Assigned to TOSOH CORPORATION, Shunan (JP)
Appl. No. 16/643,381
Filed by TOSOH CORPORATION, Shunan (JP)
PCT Filed Aug. 22, 2018, PCT No. PCT/JP2018/030916 § 371(c)(1), (2) Date Feb. 28, 2020, PCT Pub. No. WO2019/044602, PCT Pub. Date Mar. 7, 2019.
Claims priority of application No. 2017-165409 (JP), filed on Aug. 30, 2017.
Prior Publication US 2020/0256872 A1, Aug. 13, 2020
Int. Cl. G01N 33/574 (2006.01); G01N 33/68 (2006.01)

CPC G01N 33/574 (2013.01) [G01N 33/6848 (2013.01)]

9 Claims

1. A method of detecting the intact growth and differentiation factor 15 (GDF15) propeptide level in a sample of a subject having cancer, the method comprising:

measuring the intact GDF15 propeptide level in the sample, and

comparing the intact GDF15 propeptide level obtained by the measurement with a reference value calculated from a control,

wherein the intact GDF15 propeptide consists of the amino acid sequence from the leucine at the 30th residue to the arginine at the 194th residue in the GDF15 amino acid sequence of SEQ ID NO:2, and

wherein the cancer is one or more selected from the group consisting of stomach cancer, pancreatic cancer, colorectal cancer, lung cancer, breast cancer, esophageal cancer, non-small cell lung cancer, and small cell lung cancer.