US 11,913,881 B2
Bond-selective intensity diffraction tomography and uses thereof
Ji-Xin Cheng, Newton, MA (US); JIan Zhao, Boston, MA (US); Lei Tian, Newton, MA (US); and Alex Matlock, Brighton, MA (US)
Assigned to Trustees of Boston University, Boston, MA (US)
Filed by Trustees of Boston University, Boston, MA (US)
Filed on Jan. 23, 2023, as Appl. No. 18/100,347.
Claims priority of provisional application 63/389,582, filed on Jul. 15, 2022.
Prior Publication US 2024/0019369 A1, Jan. 18, 2024
Int. Cl. G01N 21/63 (2006.01); G01N 21/65 (2006.01)
CPC G01N 21/636 (2013.01) [G01N 2021/637 (2013.01); G01N 2021/655 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A microscope comprising:
a pump laser for providing a first illumination to a sample;
a laser array for providing a plurality of second illuminations to the sample, wherein the laser array comprises a plurality of laser elements, each providing oblique illuminations to the sample; and
an illumination collection source for collecting scattered illuminations from the sample, the illumination collection source producing intensity images encoding a 3D volume of the sample for each of the oblique illuminations, wherein the illumination collection source captures transient 3D refractive index (RI) variations in the sample due to the illuminations provided by the laser array using the intensity images.