US 11,913,872 B2
Spinning apparatus for measurement of characteristics relating to molecules
Darren Yang, Cambridge, MA (US); Andrew Ward, Boston, MA (US); Wesley Philip Wong, Cambridge, MA (US); and Kenneth Anders Halvorsen, Glenmont, NY (US)
Assigned to President and Fellows of Harvard College, Cambridge, MA (US); and Children's Medical Center Corporation, Boston, MA (US)
Filed by President and Fellows of Harvard College, Cambridge, MA (US); and Children's Medical Center Corporation, Boston, MA (US)
Filed on Feb. 4, 2021, as Appl. No. 17/167,847.
Application 17/167,847 is a continuation of application No. 16/079,995, granted, now 10,948,401, previously published as PCT/US2017/019318, filed on Feb. 24, 2017.
Claims priority of provisional application 62/299,711, filed on Feb. 25, 2016.
Prior Publication US 2021/0239602 A1, Aug. 5, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/07 (2006.01); G01N 33/53 (2006.01); C12Q 1/68 (2018.01); C12Q 1/6816 (2018.01); G01N 33/543 (2006.01); G01N 15/14 (2006.01); G01N 33/557 (2006.01); G01N 15/00 (2006.01); G01N 15/10 (2006.01); B82Y 15/00 (2011.01); B04B 13/00 (2006.01); B04B 15/02 (2006.01)
CPC G01N 21/07 (2013.01) [B82Y 15/00 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6816 (2013.01); G01N 15/1434 (2013.01); G01N 33/53 (2013.01); G01N 33/543 (2013.01); G01N 33/557 (2013.01); B04B 13/00 (2013.01); B04B 15/02 (2013.01); G01N 2015/0038 (2013.01); G01N 2015/0065 (2013.01); G01N 2015/1006 (2013.01); G01N 2201/021 (2013.01); G01N 2201/0423 (2013.01); G01N 2201/0693 (2013.01); G01N 2203/0089 (2013.01)] 10 Claims
OG exemplary drawing
 
1. An apparatus for measuring a characteristic of a sample, the apparatus being a spinning force system, and comprising:
a module comprising:
a sample holder;
a light source configured to illuminate the sample;
an imaging axis oriented along a direction at which light from the light source hits the sample holder; and
a detector configured to receive light from the light source,
wherein the spinning force system is arranged such that a direction of centrifugal force applied to the sample holder by a centrifuge and the imaging axis are misaligned in order to be configured to track lateral particle motion.