CPC C12N 9/78 (2013.01) [C12N 9/22 (2013.01); C12Y 305/04005 (2013.01)] | 21 Claims |
1. A cytidine deaminase protein variant comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 15 [rAPOBEC1], wherein the amino acid sequence of the cytidine deaminase protein variant includes at least three mutations at a position selected from the group consisting of R33, G45, N57, N65, Y75, T101, F113, A123, S149, A165, H166, T204, F205, and W224 of SEQ ID NO: 15 [rAPOBEC1], and wherein the cytidine deaminase protein variant has deaminase activity.
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