US 11,912,894 B2
Antimicrobial and antifouling conformal hydrogel coatings
Minglin Ma, Ithaca, NY (US); You Yong, Ithaca, NY (US); Mingyu Qiao, Ithaca, NY (US); and Qingsheng Liu, Ithaca, NY (US)
Assigned to CORNELL UNIVERSITY, Ithaca, NY (US)
Filed by CORNELL UNIVERSITY, Ithaca, NY (US)
Filed on Nov. 26, 2019, as Appl. No. 16/696,469.
Claims priority of provisional application 62/771,246, filed on Nov. 26, 2018.
Prior Publication US 2020/0172741 A1, Jun. 4, 2020
Int. Cl. A61L 31/14 (2006.01); A61L 15/46 (2006.01); A61L 29/14 (2006.01); A61L 17/00 (2006.01); A61L 31/10 (2006.01); A61L 29/08 (2006.01); A61L 15/60 (2006.01); A61L 29/16 (2006.01); A61L 17/14 (2006.01); A61L 31/16 (2006.01); C09D 5/16 (2006.01); B05D 3/10 (2006.01); B05D 3/06 (2006.01)
CPC C09D 5/1625 (2013.01) [A61L 15/60 (2013.01); A61L 17/005 (2013.01); A61L 29/085 (2013.01); A61L 29/145 (2013.01); A61L 29/16 (2013.01); B05D 3/067 (2013.01); B05D 3/101 (2013.01); B05D 3/108 (2013.01); C09D 5/1662 (2013.01); C09D 5/1687 (2013.01); B05D 2201/02 (2013.01); B05D 2320/00 (2013.01)] 14 Claims
 
1. A substrate having a conformal hydrogel coating prepared by the process of:
applying an aqueous pre-hydrogel solution to a substrate, wherein the aqueous pre-hydrogel solution comprises a mixture of a monomer with antimicrobial activity, a monomer with antifouling activity, and a polymer selected from the group of agar, chitosan, an N-isopropylacrylamide copolymer, a poloxamer, a poly(ethylene oxide)/poly(lactic acid) block copolymer, poly(ethylene oxide)/poly(propylene oxide) block copolymers, alginate, dextran, and copolymers thereof, which mixture when polymerized together forms a hydrogel;
polymerizing the aqueous pre-hydrogel solution, thereby forming a coated substrate having a conformal hydrogel coating and a non-conformal hydrogel coating;
contacting the coated substrate with a swelling agent; and
removing the non-conformal hydrogel coating from the coated substrate, thereby leaving the conformal hydrogel coating on the substrate to form the hydrogel-coated substrate.