US 11,912,800 B2
Amide-functionalized polymerization initiators and their use in the manufacture of ophthalmic lenses
Michael F. Widman, Jacksonville, FL (US); Ghulam Maharvi, Jacksonville, FL (US); Shivkumar Mahadevan, Jacksonville, FL (US); Azaam Alli, Jacksonville, FL (US); Alexander Guzman, Jacksonville, FL (US); Xin Wei, Irvine, CA (US); and Minghan Chen, Jacksonville, FL (US)
Assigned to Johnson & Johnson Vision Care, Inc., Jacksonville, FL (US)
Filed by Johnson & Johnson Vision Care, Inc., Jacksonville, FL (US)
Filed on Aug. 22, 2022, as Appl. No. 17/821,315.
Claims priority of provisional application 63/249,646, filed on Sep. 29, 2021.
Prior Publication US 2023/0105992 A1, Apr. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C08F 22/38 (2006.01); A61K 9/00 (2006.01); A61K 31/785 (2006.01)
CPC C08F 22/38 (2013.01) [A61K 9/0048 (2013.01); A61K 31/785 (2013.01)] 18 Claims
 
1. A compound of formula I:

OG Complex Work Unit Chemistry
wherein R1 at each occurrence is independently H or methyl;
R2 and R3 at each occurrence are independently H or —X′—N(R6)(R7), provided that at least one R2 or R3 is —X′—N(R6)(R7), wherein X′ at each occurrence is independently a bond or —(CO)—, R6 at each occurrence is independently H, C1-C6 alkyl, or C1-C6 alkylcarbonyl and R7 at each occurrence is independently H, C1-C6 alkyl, or C1-C6 alkylcarbonyl, or R6 and R7 at any occurrence, together with the nitrogen atom to which they are bonded, form a heterocycloalkyl ring in which a ring carbon atom is optionally replaced with a heteroatom selected from nitrogen, oxygen, and sulfur, wherein each alkyl and alkylcarbonyl is independently optionally substituted with hydroxy, amino, amido, oxo, carboxy, alkyl carboxy, carbonyl, alkylcarbonyl, alkoxy, amido, carbamate, carbonate, halo, phenyl, or benzyl, and each heterocycloalkyl is independently optionally substituted with alkyl, hydroxy, amino, amido, oxo, carboxy, alkyl carboxy, carbonyl, alkylcarbonyl, alkoxy, amido, carbamate, carbonate, halo, phenyl, or benzyl;
R4 and R5, when present, are independently at each occurrence alkyl, cycloalkyl, alkoxy, or halo;
T is a chain termination group;
n is from 10 to 4000; and
p and q are independently 0, 1, 2, 3, 4, or 5.