US 11,912,753 B2
Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens
Nathalie Scholler, Narberth, PA (US); Katarzyna Urbanska, Philadelphia, PA (US); and Daniel J. Powell, Jr., Bala Cynwyd, PA (US)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed by THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US)
Filed on Jun. 21, 2021, as Appl. No. 17/353,414.
Application 17/353,414 is a division of application No. 16/298,310, filed on Mar. 11, 2019, granted, now 11,041,012.
Application 16/298,310 is a division of application No. 15/591,910, filed on May 10, 2017, granted, now 10,266,580, issued on Apr. 23, 2019.
Application 15/591,910 is a division of application No. 14/346,612, granted, now 9,708,384, issued on Jul. 18, 2017, previously published as PCT/US2012/056901, filed on Sep. 24, 2012.
Claims priority of provisional application 61/537,933, filed on Sep. 22, 2011.
Prior Publication US 2021/0317182 A1, Oct. 14, 2021
Int. Cl. C07K 14/725 (2006.01); C07K 14/705 (2006.01); C07K 14/465 (2006.01); C12N 15/85 (2006.01); A61K 47/68 (2017.01)
CPC C07K 14/7051 (2013.01) [A61K 47/6851 (2017.08); C07K 14/465 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C12N 15/85 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/20 (2013.01)] 14 Claims
 
1. An isolated biotin binding immune receptor (BBIR) comprising an extracellular binding domain, a transmembrane domain, a T cell receptor signaling domain, and an intracellular domain of a costimulatory molecule,
wherein the extracellular binding domain comprises avidin in monomeric or dimeric form,
wherein the BBIR comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 8-10.