US 11,912,705 B2
Cathinone derivatives, pharmaceutical formulations, and methods
Clinton E. Canal, Atlanta, GA (US); Nader Moniri, Atlanta, GA (US); and Yiming Chen, Atlanta, GA (US)
Assigned to The Corporation of Mercer University, Macon, GA (US)
Filed by The Corporation of Mercer University, Macon, GA (US)
Filed on Aug. 20, 2021, as Appl. No. 17/407,438.
Claims priority of provisional application 63/068,135, filed on Aug. 20, 2020.
Prior Publication US 2022/0056029 A1, Feb. 24, 2022
Int. Cl. C07D 471/08 (2006.01); C07D 211/32 (2006.01); C07D 491/18 (2006.01); C07D 471/04 (2006.01); C07D 223/04 (2006.01)
CPC C07D 471/08 (2013.01) [C07D 211/32 (2013.01); C07D 223/04 (2013.01); C07D 471/04 (2013.01); C07D 491/18 (2013.01)] 42 Claims
 
1. A compound of formula (I), formula (II), or formula (III), or a salt of formula (I), formula (II), or formula (III):

OG Complex Work Unit Chemistry
wherein R1 is a C1-C10 hydrocarbyl comprising a nitrogen atom;
wherein R2, R3, R4, R5, and R6 are independently selected from the group consisting of hydrogen, methyl, methoxy, hydroxy, a first halogen, and a C1-C6 hydrocarbyl comprising a covalent bond between R2 and R3, R3 and R4, R4 and R5, or R5 and R6; and
wherein X is selected from the group consisting of hydrogen, methyl, ethyl, hydroxy, and a second halogen; and
wherein (i) R1 is an 8-methyl-8-azabicyclo[3.2.1]octanyl, or (ii) the compound of formula (I), formula (II), or formula (III) is a structure, or a salt thereof, selected from the group consisting of—

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry